abstract：:Uncoupling protein 2 (UCP2) is a mitochondrial transporter present in the inner membrane of mitochondria, and it uncouples substrate oxidation from ATP synthesis, thereby dissipating the membrane potential energy and consequently decreasing ATP production by mitochondrial respiratory chain. As a consequence of the unc...

journal_title：Experimental eye research

authors： de Souza BM,Assmann TS,Kliemann LM,Marcon AS,Gross JL,Canani LH,Crispim D

更新日期：2012-01-01 00:00:00

abstract：:Fatty Liver Shionogi (FLS) mice have been shown to develop a hereditary disorder characterized by localized retinochoroidal defects of the ventral fundus very similar to human typical ocular coloboma without microphthalmia. The objective of this study was to determine when and how the failure of the optic fissure clos...

journal_title：Experimental eye research

authors： Tsuji N,Kita K,Ozaki K,Narama I,Matsuura T

更新日期：2012-01-01 00:00:00

abstract：:Aquaporin-0 (AQP0), the major integral membrane protein in lens fiber cells, becomes highly modified with increasing age. The functional consequences of these modifications are being revealed, and the next step is to determine how these modifications affect the ocular lens, which is directly related to their abundance...

journal_title：Experimental eye research

authors： Gutierrez DB,Garland D,Schey KL

更新日期：2011-12-01 00:00:00

abstract：:Much controversy has arisen on the nature and sources of stem cells in the adult human retina. Whilst ciliary epithelium has been thought to constitute a source of neural stem cells, a population of Müller glia in the neural retina has also been shown to exhibit neurogenic characteristics. This study aimed to compare ...

journal_title：Experimental eye research

authors： Bhatia B,Jayaram H,Singhal S,Jones MF,Limb GA

更新日期：2011-12-01 00:00:00

abstract：:Neovascular eye diseases such as wet age-related macular degeneration and proliferative diabetic retinopathy are two of the most common causes of irreversible visual loss. Although mediated by vascular endothelial growth factor (VEGF), the mechanisms of these diseases are not fully understood. Molecular inhibitors of ...

journal_title：Experimental eye research

authors： Stewart EA,Samaranayake GJ,Browning AC,Hopkinson A,Amoaku WM

更新日期：2011-11-01 00:00:00

abstract：:Some previous studies have showed that transcorneal electrical stimulation (TES) could protect retinal neurons in certain rodent models. However, it is not yet clear whether TES could also definitely protect retinal neurons against ischemic insults. In the present study, we hypothesized that TES had such a neuroprotec...

journal_title：Experimental eye research

authors： Wang X,Mo X,Li D,Wang Y,Fang Y,Rong X,Miao H,Shou T

更新日期：2011-11-01 00:00:00

abstract：:Thrombospondin-1 (TSP-1) is a multifunctional matrix protein that has recently been examined in various wound processes, primarily for its ability to activate the latent complex of transforming growth factor-beta (TGF-β). TGF-β has been shown to play a major role in stimulating mesenchymal cells to synthesize extracel...

journal_title：Experimental eye research

authors： Matsuba M,Hutcheon AE,Zieske JD

更新日期：2011-10-01 00:00:00

abstract：:Our previous studies in bovine eyes demonstrated that the structural correlate to the increase in outflow facility after either Rho-kinase inhibitor Y-27632 (Y27) treatment or washout appeared to be separation between the juxtacanalicular tissue (JCT) and inner wall (IW) of the aqueous plexus, the bovine equivalent of...

journal_title：Experimental eye research

authors： Lu Z,Zhang Y,Freddo TF,Gong H

更新日期：2011-10-01 00:00:00

abstract：:The zebrafish retina regenerates in response to acute retinal lesions, replacing damaged neurons with new neurons. In this study we test the hypothesis that chronic stress to inner retinal neurons also triggers a retinal regeneration response in the bugeye zebrafish. Mutations in the lrp2 gene in zebrafish are associa...

journal_title：Experimental eye research

authors： Sherpa T,Hunter SS,Frey RA,Robison BD,Stenkamp DL

更新日期：2011-10-01 00:00:00

abstract：:Understanding mechanisms of glaucomatous optic nerve damage is essential for developing effective therapies to augment conventional pressure-lowering treatments. This requires that we understand not only the physical forces in play, but the cellular responses that translate these forces into axonal injury. The former ...

journal_title：Experimental eye research

authors： Morrison JC,Cepurna Ying Guo WO,Johnson EC

更新日期：2011-08-01 00:00:00

abstract：:The similarities between glaucoma and mitochondrial optic neuropathies have driven a growing interest in exploring mitochondrial function in glaucoma. The specific loss of retinal ganglion cells is a common feature of mitochondrial diseases - not only the classic mitochondrial optic neuropathies of Leber's Hereditary ...

journal_title：Experimental eye research

authors： Lee S,Van Bergen NJ,Kong GY,Chrysostomou V,Waugh HS,O'Neill EC,Crowston JG,Trounce IA

更新日期：2011-08-01 00:00:00

abstract：:The Publisher regrets that this article is an accidental duplication of an article that has already been published, doi:10.1016/j.exer.2010.03.008. The duplicate article has therefore been withdrawn. ...

journal_title：Experimental eye research

authors： Osborne NN

更新日期：2011-07-29 00:00:00

abstract：:The benzopyran BP (3,4-dihydro-6-hydroxy-7-methoxy-2,2-dimethyl-1(2H)-benzopyran) is a free radical scavenger that is structurally similar to alpha-tocopherol and has provided neuro-protection in a number of disease models where oxidative stress is a causative factor. A novel derivative of BP with improved lipid solub...

journal_title：Experimental eye research

authors： O'Driscoll C,Doonan F,Sanvicens N,Messeguer A,Cotter TG

更新日期：2011-07-01 00:00:00

abstract：:The goal of this study was to investigate the efflux of K(+) from human corneal limbal epithelial cells (HCLE) exposed to ambient levels of UVB, which is known to cause apoptosis, and to examine the effect of K(+) channel blockers on loss of potassium induced by UVB. HCLE cells were exposed to 100-200 mJ/cm(2) UVB, fo...

journal_title：Experimental eye research

authors： Ubels JL,Van Dyken RE,Louters JR,Schotanus MP,Haarsma LD

更新日期：2011-05-01 00:00:00

abstract：:The transcription factor Brn3a has been reported to be a good marker for adult rat retinal ganglion cells in control and injured retinas. However, it is still unclear if Brn3a expression declines progressively by the injury itself or otherwise its expression is maintained in retinal ganglion cells that, though being i...

journal_title：Experimental eye research

authors： Sánchez-Migallón MC,Nadal-Nicolás FM,Jiménez-López M,Sobrado-Calvo P,Vidal-Sanz M,Agudo-Barriuso M

更新日期：2011-04-01 00:00:00

abstract：:Aim of this study was to examine synaptic connectivity changes in the retina and the location and rate of apoptosis in transgenic S334ter line-3 and line-5 rats with photoreceptor degeneration. Heterozygous S334ter-line-3 and line-5 at P11-13, P30, P60, P90 and several control non-dystrophic rats (Long Evans and Sprag...

journal_title：Experimental eye research

authors： Martinez-Navarrete G,Seiler MJ,Aramant RB,Fernandez-Sanchez L,Pinilla I,Cuenca N

更新日期：2011-03-01 00:00:00

abstract：:The current study investigates potential differences in fibroblast phenotype across the anterior segment of the human eye with the aim to understanding factors that support the regenerative function of human limbal epithelial progenitor cells (LEPs) during wound healing. Separate cultures of fibroblasts were establish...

journal_title：Experimental eye research

authors： Ainscough SL,Linn ML,Barnard Z,Schwab IR,Harkin DG

更新日期：2011-01-01 00:00:00

abstract：:The P23H-1 rat strain carries a rhodopsin mutation frequently found in retinitis pigmentosa patients. We investigated the progressive degeneration of the inner retina in this strain, focussing on retinal ganglion cells (RGCs) fate. Our data show that photoreceptor death commences in the ventral retina, spreading to th...

journal_title：Experimental eye research

authors： García-Ayuso D,Salinas-Navarro M,Agudo M,Cuenca N,Pinilla I,Vidal-Sanz M,Villegas-Pérez MP

更新日期：2010-12-01 00:00:00

abstract：:The aim of this study was to test the selectivity, in-vivo effectiveness, and potential mechanism of action of a linomide analogue (N-phenyl-1,2-dihydro-4-hydroxyl-2-oxo-quinoline-3-carboxamide, Lin05) for inhibition of choroidal neovascularization. The selectivity of Lin05 was tested in cell proliferation assays with...

journal_title：Experimental eye research

authors： Abdel-Rahman MH,Yang Y,Salem MM,Meadows S,Massengill JB,Li PK,Davidorf FH

更新日期：2010-12-01 00:00:00

abstract：:Harmonic analysis was used to characterize the rabbit flicker ERG elicited by sinusoidally modulated full-field stimuli under light-adapted conditions. The frequency-response function for fundamental amplitude, derived from Fourier analysis of the ERG waveforms, exhibited two limbs, with an amplitude minimum at approx...

journal_title：Experimental eye research

authors： Qian H,Alexander KR,Ripps H

更新日期：2010-12-01 00:00:00

abstract：:We developed an approach to generate a three-dimensional map that facilitates the assessment of epithelial nerve density in different corneal areas to define aging and gender influence on human corneal nerve architecture. Twenty-eight fresh human eyes from 14 donors of different ages were studied. Corneal nerves were ...

journal_title：Experimental eye research

authors： He J,Bazan NG,Bazan HE

更新日期：2010-10-01 00:00:00

abstract：:Retinal degeneration (RD) results from photoreceptor apoptosis. Cell transplantation, one potential therapeutic approach, requires expandable stem cells that can form mature photoreceptors when differentiated. Freshly dissociated primary retinal cells from postnatal day 2-6 (PN2-6) mouse retina can give rise, post-tra...

journal_title：Experimental eye research

authors： Mansergh FC,Vawda R,Millington-Ward S,Kenna PF,Haas J,Gallagher C,Wilson JH,Humphries P,Ader M,Farrar GJ

更新日期：2010-10-01 00:00:00

abstract：:Corneal epithelial injury induces release of endogenous metabolites that are cannabinoid receptor 1 (CB1) and transient receptor potential vanilloid 1 (TRPV1) agonists. We determined the functional contributions by CB1 and TRPV1 activation to eliciting responses underlying wound healing in human corneal epithelial cel...

journal_title：Experimental eye research

authors： Yang H,Wang Z,Capó-Aponte JE,Zhang F,Pan Z,Reinach PS

更新日期：2010-09-01 00:00:00

abstract：:Choroidal neovascularization (CNV) is one of the severe pathological consequences of the end-stage of age-related macular degeneration (AMD). Several lines of evidence implicate increased levels of vascular endothelial growth factor (VEGF) in the retinas of AMD patients. Current available agents for the inhibition of ...

journal_title：Experimental eye research

authors： Gu L,Chen H,Tuo J,Gao X,Chen L

更新日期：2010-09-01 00:00:00

abstract：:The protein phosphatase 2B inhibitor, FK506, is an immunomodulatory polypeptide that has neuroprotective properties, the mechanisms of which have not been elucidated. A possible mechanism may be phosphorylation-mediated regulation of glutamate transporter activity. In the present study, we investigated the effect of F...

journal_title：Experimental eye research

authors： Holcombe DJ,Gole GA,Barnett NL

更新日期：2010-08-01 00:00:00

abstract：:The immunolocalization of the low density lipoprotein receptor-related protein 1 (LRP1) and its ligand alpha 2-Macroglobulin (alpha(2)M) was examined in tissues from human donor eyes of normal, diabetic and sickle cell disease subjects. Streptavidin alkaline phosphatase immunohistochemistry was performed with a mouse ...

journal_title：Experimental eye research

authors： Barcelona PF,Luna JD,Chiabrando GA,Juarez CP,Bhutto IA,Baba T,McLeod DS,Sánchez MC,Lutty GA

更新日期：2010-08-01 00:00:00

abstract：:This review is focused on iron metabolism in the retina and in the lens and its relation to their respective age-related pathologies, macular degeneration (AMD) and cataract (ARC). Several aspects of iron homeostasis are considered first in the retina and second in the lens, paying particular attention to the transpor...

journal_title：Experimental eye research

authors： García-Castiñeiras S

更新日期：2010-06-01 00:00:00

abstract：:The R49C mutation of alphaA-crystallin (alphaA-R49C) causes hereditary cataracts in humans; patients in a four-generation Caucasian family were found be heterozygous for this autosomal dominant mutation. We previously generated knock-in mouse models of this mutation and found that by 2 months of age, heterozygous muta...

journal_title：Experimental eye research

authors： Andley UP,Reilly MA

更新日期：2010-06-01 00:00:00

abstract：:Erythropoietin (EPO) plays a critical role in the vascular system and exhibits angiogenic activity in endothelial cells (ECs) such as stimulation of cell proliferation, migration and tube formation in vitro. EPO is the major regulator of cell proliferation and differentiation of erythroid precursors and there by preve...

journal_title：Experimental eye research

authors： Haribalaganesh R,Sheikpranbabu S,Banumathi E,Gurunathan S

更新日期：2010-06-01 00:00:00

abstract：:The purpose of present study is to dissect the role of PI3K/AKT signaling in the anti-apoptotic effects of human granulocyte colony-stimulating factor (G-CSF) on rat retinal ganglion cells (RGCs) after optic nerve (ON) crush. The ONs of seventy-two adult male Wistar rats were crushed by a standardized method. Control ...

journal_title：Experimental eye research

authors： Tsai RK,Chang CH,Sheu MM,Huang ZL

更新日期：2010-05-01 00:00:00

abstract：:The study aimed to determine the variation in thickness and biomechanical properties between the different regions of the human sclera. Thickness measurements were carried out along eight meridian lines extending from the posterior pole to limbus in 36 human donor scleras aged 52-96 years. Strip specimens were extract...

journal_title：Experimental eye research

authors： Elsheikh A,Geraghty B,Alhasso D,Knappett J,Campanelli M,Rama P

更新日期：2010-05-01 00:00:00

abstract：:Diabetic retinopathy shares many characteristics features of a low grade chronic inflammatory disease. Its progression resists arrest when good metabolic control is re-established after a period of poor metabolic control, suggesting a 'metabolic memory' phenomenon. The aim of this study is to investigate the effect of...

journal_title：Experimental eye research

authors： Kowluru RA,Zhong Q,Kanwar M

更新日期：2010-05-01 00:00:00

abstract：:The transcription factor Prox1 acts in rodent retinogenesis, at least in promoting cell cycle withdrawal and horizontal cell production. In the mature retina, this protein is detected at the inner nuclear layer of all vertebrate groups. We have made a neurochemical characterisation of Prox1(+) cell types in two differ...

journal_title：Experimental eye research

authors： Cid E,Santos-Ledo A,Parrilla-Monge M,Lillo C,Arévalo R,Lara JM,Aijón J,Velasco A

更新日期：2010-02-01 00:00:00

abstract：:The heparan sulfate (HS) is a component of proteoglycans in the extracellular matrix and on cell surfaces, modulating developmental processes. The aim of this study is to investigate whether the defect of HS in the periocular mesenchyme impairs ocular morphogenesis. First, using Protein 0-Cre transgenic mice, we ablat...

journal_title：Experimental eye research

authors： Iwao K,Inatani M,Ogata-Iwao M,Yamaguchi Y,Okinami S,Tanihara H

更新日期：2010-01-01 00:00:00

abstract：:Nitric oxide (NO) production by vascular endothelium is important in regulation of blood flow. Reduced production of NO can adversely affect blood flow and other vascular functions. We investigated the expression of three nitric oxide synthase (NOS) isoforms in retina and choroid of aged human eyes and eyes with AMD. ...

journal_title：Experimental eye research

authors： Bhutto IA,Baba T,Merges C,McLeod DS,Lutty GA

更新日期：2010-01-01 00:00:00

abstract：:Osteopontin (OPN) is elevated during the progression of experimental autoimmune uveoretinitis (EAU) in C57BL/6 (B6) mice. Furthermore, EAU symptoms are ameliorated in OPN knockout mice or in B6 mice treated with anti-OPN antibody (M5). Recently, OPN has been shown to promote the Th1 response not only in the extracellu...

journal_title：Experimental eye research

authors： Iwata D,Kitamura M,Kitaichi N,Saito Y,Kon S,Namba K,Morimoto J,Ebihara A,Kitamei H,Yoshida K,Ishida S,Ohno S,Uede T,Onoé K,Iwabuchi K

更新日期：2010-01-01 00:00:00

abstract：:Although it is important to investigate the effects of normal aging on the ocular circulation, few studies have examined the effects of aging on the retinal microcirculation in healthy subjects. The purpose of this study was to evaluate the effects of aging on the retinal microcirculation in healthy men. Forty-five he...

journal_title：Experimental eye research

authors： Nagaoka T,Sato E,Takahashi A,Sogawa K,Yokota H,Yoshida A

更新日期：2009-12-01 00:00:00

abstract：:Prostaglandins are widely used to lower intraocular pressure (IOP) as part of the treatment regimen for glaucoma. While FP and EP2 agonists are known to lower IOP, we investigated the ocular hypotensive activity and ocular drug distribution of PF-04475270, a novel EP4 agonist following topical administration in normot...

journal_title：Experimental eye research

authors： Prasanna G,Fortner J,Xiang C,Zhang E,Carreiro S,Anderson S,Sartnurak S,Wu G,Gukasyan H,Niesman M,Nair S,Rui E,Lafontaine J,Almaden CD,Wells P,Krauss A

更新日期：2009-11-01 00:00:00

abstract：:In the neural retina, glial cells control formation of ionic gradients by mediating transmembrane water fluxes through aquaporin (AQP) water channels. Retinal content and immunolocalization of two water channels, AQP1 and AQP4, in the diabetic rat retinas during high-salt loading were examined in this study. Diabetes ...

journal_title：Experimental eye research

authors： Qin Y,Xu G,Fan J,Witt RE,Da C

更新日期：2009-11-01 00:00:00

abstract：:Hypoxia-inducible factor (HIF) signaling cascade plays a critical role in angiogenesis by activating the transcription of genes encoding angiogenic growth factors. This study evaluated the effects of YC-1, a HIF-1 inhibitor, on the morphological, biochemical and molecular changes in human retinal microvascular endothe...

journal_title：Experimental eye research

authors： DeNiro M,Alsmadi O,Al-Mohanna F

更新日期：2009-11-01 00:00:00